14.11 Red cell folate

Red cell folate data available for STOP cohort only.


14.11.1 Global tests

Type III ANOVA on main and interaction effects, and LM model summaries.

PRL (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 85.988271 1 <0.0001 ***
ns(rcfolate, 3) 4.943268 3 0.2 ns
GA_samp 87.352352 1 <0.0001 ***
hPL (μg/ml)
Chisq Df Pr(>Chisq)
(Intercept) 3.511184 1 0.06 ns
ns(rcfolate, 3) 1.672576 3 0.6 ns
GA_samp 1649.063858 1 <0.0001 ***
GH2 (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 141.614158 1 <0.0001 ***
ns(rcfolate, 3) 5.404287 3 0.1 ns
GA_samp 765.463640 1 <0.0001 ***
Insulin (uU/ml)
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.303 0.303 0.6 ns
GA_samp 1 Inf 1.955 1.955 0.2 ns
HOMA-IR
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.387 0.387 0.5 ns
GA_samp 1 Inf 1.423 1.423 0.2 ns
Glucose (mmol/L)
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.356 0.356 0.6 ns
GA_samp 1 Inf 1.484 1.484 0.2 ns

14.11.2 Model summary

Ratio of Geometric means (95% CI)

PRL (ng/ml)
Var Effect P
(Intercept) 21.49 (11.25, 41.07) <0.0001
ns(rcfolate, 3)1 0.89 (0.60, 1.33) 0.57
ns(rcfolate, 3)2 0.79 (0.24, 2.63) 0.70
ns(rcfolate, 3)3 1.07 (0.93, 1.25) 0.34
GA_samp 1.13 (1.10, 1.16) <0.0001
hPL (μg/ml)
Var Effect P
(Intercept) 1.44 (0.98, 2.10) 0.06
ns(rcfolate, 3)1 1.10 (0.87, 1.40) 0.43
ns(rcfolate, 3)2 1.40 (0.69, 2.85) 0.36
ns(rcfolate, 3)3 0.99 (0.91, 1.08) 0.87
GA_samp 1.36 (1.34, 1.38) <0.0001
GH2 (ng/ml)
Var Effect P
(Intercept) 0.05 (0.03, 0.08) <0.0001
ns(rcfolate, 3)1 1.05 (0.77, 1.45) 0.75
ns(rcfolate, 3)2 1.59 (0.61, 4.14) 0.34
ns(rcfolate, 3)3 0.93 (0.83, 1.04) 0.21
GA_samp 1.33 (1.30, 1.36) <0.0001
Insulin (uU/ml)
Var Effect P
(Intercept) 9.80 (5.14, 18.67) <0.0001
ns(rcfolate, 3)1 0.89 (0.61, 1.30) 0.56
ns(rcfolate, 3)2 0.82 (0.26, 2.59) 0.74
ns(rcfolate, 3)3 1.17 (0.99, 1.38) 0.06
GA_samp 1.02 (0.99, 1.06) 0.16
HOMA-IR
Var Effect P
(Intercept) 2.21 (1.09, 4.48) 0.03
ns(rcfolate, 3)1 0.87 (0.58, 1.32) 0.51
ns(rcfolate, 3)2 0.76 (0.21, 2.72) 0.67
ns(rcfolate, 3)3 1.17 (0.99, 1.39) 0.07
GA_samp 1.02 (0.99, 1.06) 0.23
Glucose (mmol/L)
Var Effect P
(Intercept) 5.08 (4.36, 5.93) <0.0001
ns(rcfolate, 3)1 0.99 (0.90, 1.09) 0.82
ns(rcfolate, 3)2 0.94 (0.68, 1.29) 0.69
ns(rcfolate, 3)3 1.03 (1.00, 1.07) 0.07
GA_samp 1.00 (0.99, 1.00) 0.22

14.11.3 Diagnostics

Model diagnositcs.

Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

14.11.4 Plots